Arsenal and Barcelona will go head to head once again after the two teams were drawn against each other in the last 16 Champions League.

Barcelona beat Arsenal 6-3 over two legs in their quarter-final clash last season and are favourites with the bookmakers to eliminate The Gunners for a second year in a row.

However, the Barcelona manager Pep Guardiola talked up the danger posed by Arsenal in the wake of the draw.

‘Arsenal are a classic of English football. They have been playing good for football for years now. I think they will be stronger than they were last season with Nasri now fully established in the team, plus the signing of Chamakh. Also there's a difference this time: Cesc will be on the pitch.’

Guardiola continued: ‘Arsenal frighten me, but that is true of all the clubs in the draw. I see difficulties in all of them. I will be a little calmer when I start to watch their games, if I can see any weaknesses.’

Champions League debutants Tottenham were also handed a tough draw against Serie A leaders and seven times European Champions AC Milan.

Spurs manager Harry Redknapp seemed delighted with the draw: ‘It will be a great game. I would have taken AC Milan before the draw. They are leading the league in Italy but it has the makings of a great game over two legs. I'm looking forward to it.’

Chelsea were given a relatively easy draw against Danish champions FC Copenhagen while Manchester United face Ligue 1 Champions Marseille.

The full draw for the last 16 of the Champions League: Roma v Shakhtar Donetsk; AC Milan v Tottenham; Valencia v Schalke; Inter Milan v Bayern Munich; Lyon v Real Madrid; Arsenal v Barcelona; Marseille v Manchester United; FC Copenhagen v Chelsea.